The DEO captures a second Worldkiller, Purity. Supergirl and Alex use very different methods of interrogation with Purity in the hopes of finding out how to defeat Reign. However, Purity…

Myr’nn inadvertently causes psychic disturbances at the DEO; Supergirl must work with J’onn to contain the chaos; Mon-El begins training Kara in fighting techniques he’s learned in the future.

Supergirl and Imra have different ideas on how to stop the third Worldkiller, Pestilence. However, when both Alex and Winn are seriously injured by Pestilence, Supergirl and Imra team up…

Still reeling after learning about Lena’s secret, Supergirl asks Guardian for a favor that could alter his relationship with Lena forever. Meanwhile, with all three Worldkillers united, Supergirl and the…

As Reign continues to terrorize the city, Supergirl teams up with Saturn Girl, and the two recruit Supergirl’s former enemies, Livewire and Psi, to form a team for a mission…

Someone tries to kill Morgan Edge and he barely survives. He accuses Lena of being behind the attempt and vows to destroy her. When Lena fears her hatred for Morgan…